Portuguese Brain Bank Tissue Request
The Portuguese Brain Bank (PBB) can supply formalin-fixed and fresh-frozen brain tissue for research purposes. You must complete and return a tissue request form.
- PBB 001 Tissue Request Form
- PBB 002 Supplementary Tissue Request Form
The request will then be reviewed by our management committee who will assess the application on its scientific merit and ethical use of tissues. If necessary, additional information may be sought from the researchers.
If you have any questions, please contact the Portuguese Brain Bank ptbrainbank@chporto.min-saude.pt
Neuropathological Diagnoses
Publications from the PBB
#16 A Spanish-Portuguese GWAS of progressive supranuclear palsy reveals a novel risk locus in NFASC.
García-González P, Rodrigo Lara H, Compta Y et al.
European Journal of Human Genetics
2025 Jul;33(7):960-965. doi: 10.1038/s41431-025-01872-3.
#15 Pathogenesis, manifestations, diagnosis, and management of CNS complications in hereditary ATTR amyloidosis
Yoshiki Sekijima, Luísa Sousa
Amyloid.
2025 Jun;32(2):117-128. doi: 10.1080/13506129.2024.2435573.
#14 Exome sequencing of a Portuguese cohort of early-onset Alzheimer’s disease implicates the X-linked lysosomal gene GLA.
Tábuas-Pereira M, Brás J, Taipa R, Del Tredici K, Paquette K, Chaudhry S, DenHaan K, Durães J, Lima M, Bernardes C, Carmona S, Baldeiras I, Almeida R, Santana I, Guerreiro R.
Scientific Reports
2025 Apr 4;15(1):11653. doi: 10.1038/s41598-025-95183-8.
#13 α-Synuclein triggers cofilin pathology and dendritic spine impairment via a PrPC-CCR5 dependent pathway
Marina I Oliveira da Silva, Miguel Santejo, Isaac W Babcock, Ana Magalhães, Laurie S Minamide, Seok-Joon Won, Erika Castillo, Ellen Gerhardt, Christiane Fahlbusch, Raymond A Swanson, Tiago F Outeiro, Ricardo Taipa, Michael Ruff, James R Bamburg , Márcia A Liz.
Cell Death & Disease
2024 Apr 13;15(4):264. doi: 10.1038/s41419-024-06630-9.
#12 Rapidly Progressive Corticobasal Degeneration Mimicking Brainstem Encephalitis.
Moura J, Oliveira V, Sardoeira A, Pinto M, Gelpi E, Taipa R, Santos E.
Mov Disord Clin Pract.
2022 Dec 15;10(2):300-306. doi: 10.1002/mdc3.13633. eCollection 2023 Feb. PMID: 36825044
#11 Neuropathology of central nervous system involvement in TTR amyloidosis.
Taipa R, Sousa L, Pinto M, Reis I, Rodrigues A, Oliveira P, Melo-Pires M, Coelho T.
Acta Neuropathol.
2022 Oct 6. doi: 10.1007/s00401-022-02501-9. Online ahead of print. PMID: 36198883
#10 Parkinson’s disease and multiple system atrophy patient iPSC-derived oligodendrocytes exhibit alpha-synuclein-induced changes in maturation and immune reactive properties.
Azevedo C, Teku G, Pomeshchik Y, Reyes JF, Chumarina M, Russ K, Savchenko E, Hammarberg A, Lamas NJ, Collin A, Gouras GK, Klementieva O, Hallbeck M, Taipa R, Vihinen M, Roybon L.
Proc Natl Acad Sci U S A.
2022 Mar 22;119(12):e2111405119. doi: 10.1073/pnas.2111405119
#09 CNS Involvement in Hereditary Transthyretin Amyloidosis.
Sousa L, Coelho T, Taipa R.
Neurology.
2021 Dec 14;97(24):1111-1119. doi: 10.1212/WNL.0000000000012965
#08 Letter to the Editor on “Copathology in Progressive Supranuclear Palsy: Does It Matter?”
Videira G, Damásio J, Pinto C, Melo-Pires M, Taipa R.
Mov Disord.
2020 Nov;35(11):2124-2126. doi: 10.1002/mds.28308
#07 Using global team science to identify genetic parkinson’s disease worldwide.
Vollstedt EJ, Kasten M, Klein C; MJFF Global Genetic Parkinson’s Disease Study Group.
Ann Neurol.
2019 Aug;86(2):153-157. doi: 10.1002/ana.25514. Epub 2019 Jun 26.
#06 Evidence of amyloid-β cerebral amyloid angiopathy transmission through neurosurgery.
Jaunmuktane Z, Quaegebeur A, Taipa R, Viana-Baptista M, Barbosa R, Koriath C, Sciot R, Mead S, Brandner S.
Acta Neuropathol.
2018 May;135(5):671-679. doi: 10.1007/s00401-018-1822-2
#05 When Decrease Aβ1-42 in CSF May Not Mean Alzheimer’s Disease: Insights From Two Case Reports With Early Onset Dementia.
Ladeira F, Cação G, Correia AP, Pinto PS, Cavaco S, Melo-Pires M, Alonso I, Taipa R.
Alzheimer Dis Assoc Disord.
2018 Oct-Dec;32(4):359-363. doi:10.1097/WAD.0000000000000248
#04 Vascular Pathology Causing Late Onset Generalized Chorea: A Clinico-Pathological Case Report.
Salgado P, Taipa R, Domingos J, Dias D, Pires MM, Magalhães M.
Mov Disord Clin Pract.
2017 Sep 8;4(6):819-823. doi: 10.1002/mdc3.12528
#03 Patterns of Microglial Cell Activation in Alzheimer Disease and Frontotemporal Lobar Degeneration.
Taipa R, Brochado P, Robinson A, Reis I, Costa P, Mann DM, Melo Pires M, Sousa N.
Neurodegener Dis.
2017;17(4-5):145-154. doi: 10.1159/000457127. Epub 2017 Apr 27.
#02 Frontotemporal lobar degeneration-TDP with ‘multiple system atrophy phenocopy syndrome’.
Sousa AL, Taipa R, Quinn N, Revesz T, Pires MM, Magalhães M.
Neuropathol Appl Neurobiol.
2017 Oct;43(6):533-536. doi: 10.1111/nan.12391
#01 DJ-1 linked parkinsonism (PARK7) is associated with Lewy body pathology.
Taipa R, Pereira C, Reis I, Alonso I, Bastos-Lima A, Melo-Pires M, Magalhães M.
Brain.
2016 Jun;139(Pt 6):1680-7. doi: 10.1093/brain/aww080
Portuguese Brain Bank
Neuropathology Unit – Department of Neurosciences
Centro Hospitalar Universitário do Porto
Largo Prof. Abel Salazar – 4099-001 Porto
geral@bancodecerebros.chporto.pt
Tel +351 913504401